I have a 2007 6.0 with 125000 miles. I use Motorcraft fuel filters only to insure I have the vent hole in the correct position. The truck is not modified in anyway.The issue I am having is after about 2000 miles the engine will die. It will not start until I change the lower filter (I change both) while on the side of the road. I have a fuel pressure gauge and when the engine dies I have 0 fuel pressure.Fuel pressure is always 53-60 psi (doesn't fluctuate...60 when cold the gradually drops to around 55 when warmed up) even just before it dies. Engine runs perfectly otherwise. Upon inspection the filter is clean at the vent hole down and just grey in color over the rest of the filter.I pulled the tank and it is unbelievably clean...no water or grime. I never use biodiesel and fuel only from major brand stations that do not contain the 5% biodiesel.My guess is an issue with the low vacuum that draws the fuel from the tank to the fuel pump. When the filter reaches a certain amount of contamination the PCM shuts the fuel pump off. I've checked the line and found no issues. I never seem or heard of anyone having this issue unless they are not using the Motorcraft filters.Is it the fuel pump or is there another issue affecting the PCM which causes it to shut the pump down. It's probably something simple that I am over looking.Any other ideas or possible solutions would greatly be appreciated.