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Tune a stock truck, you raise the cylinder pressure, that is why most of us use head studs since the raised cylinder pressure is more than the torque to yield head bolt can handle. A stock 6.0L has more HP and better transmission than a chipped 7.3L you are used to.
Yes you can tune a 6.0L but be aware of Pay to Play if you tow with added HP on stock head bolts.