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SCT devices are the best for 6.0s, with tunes from Gearhead, Innovative, etc... you will typically achieve the best MPG gain on a high HP/race tune vs. an economy tune, as long as you can keep your foot out of it...
But your ROI is a long turnaround @ 1 or 2 mpg improvement...
The two 6.0's I had tuned with SCT were for fun more than any mpg savings
Less than $350 for an SCT 3015...
1000 miles a month, 15 mpg = 66.6 gallons @ $3.75 = $250
1000 miles a month, 16 mpg = 62.5 gallons @ $3.75 = $234 22 months to break even
1000 miles a month, 17 mpg = 58.8 gallons @ $3.75 = $220 12 months to break even
Obviously the more one drives the more ROI one would achieve.
I have the same truck, a 2004.
When funding is available...(DAMN WEDDING) I will be purchasing a SCT tuner from Gearhead Performance. They seem to have very good reviews and offer tunes safe for a non-studded truck. I plan on using there 8K tow tune. Go on their website they have alot of info.