My turbo is shot and I'm looking for a new, can get one off a 2000 truck with 150,000 miles on it for $300 or is there something out there that's upgraded and worth the cash.

Second thing is need a tranny cooler, was suggested this Xtrude cooler but seeing what all you guys have tried. Thanks a ton.

BD Diesel Performance Xtrude Transmission Oil Coolers| Trucking Times MagazineTrucking Times

 

That thread title will draw plenty of input - it's akin to "Somebody spend my money."

The transmission cooler from the 6.0L Powerstroke is the most widely recommended cooler here. While I don't have cooling issues (yet), it makes sense to me: It is a bolt in, it's a "factory" mod, it's straightforward (no fans-n-stuff), and there are tons of installs out there - so there are plenty of testimonials from rigs with your engine and transmission.

If the turbo is dusted, you can rebuild it cheaply enough - so it doesn't sound like a big risk for that price. Others know more than I do, though... I upgraded.

 

I was pulling 16' loaded trailer up the Rocky Mountains and I had to keep shutting it down to cool an creep up so something is getting added

 

If you are running stock injectors then the stock turbo is just fine. Many times they can be rebuilt.
Garrett GTP38 Turbo Rebuild kit

If you need a new wheel then you can find them on ebay for a few dollars. There is a guy that buys new stock turbos and installs a early style wheel and sells it as a Banks turbo knock off.....he blows out the original wheels for a few bucks and they are still brand new.

The 6.0 cooler is very good.
The Tru-Cool Max 47391 is OK but this cooler also works very well
transmissioncoolers.us: Tru-Cool LPD, thick cooler & standard installation kit

I have used them all and the 6.0 cooler is probably the best but I can't help but think that the full benefit is seen by also using the 6.0 transmission cooler lines along with the cooler itself. At that point the price gets up there a bit. The 47391 works OK but it is a bit more restrictive than I'd like....still flows to spec but it doesn't flow as well as the 6.0 unit.

The 4590 is a high flow low pressure drop unit. It does a pretty darn good job when coupled to the OEM 7.3 cooler on these trucks.