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Never switched to the synthetic oil here, but I've owned a 97 F250 7.3 that had like 275,000 miles on it, and now own a 2000 F250 7.3 with 155,000 miles on it. Always used Rotella, never had a problem!
I have used the Mobil Delvac 1 synthetic in all my trucks. Everything from my PSD to the Cat 3406's in the big trucks I used to own. In the long run, I found synthetic to be a cost savings in both fuel and maintenance versus mineral due to improved economy and extended drain intervals.
I run AMSoil Synthetics in all my cars and wouldn't run anything different. It is a bit more expensive, but results in less frequent oil changes and noticeable improvements in multiple areas. Just my opinion.