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I always thought a John Deere diesel would make a good swap. Ford should get a deal struck up with them. Check here for an engine I think would make a good candidate.
Thanks Lectrocuted I drive heavy haul truck for a living. But it is hard to find some one who can actually explain why we have in-lines and not V's in big trucks, and why the opposite in PU trucks.
Another thing is packaging. A v-8 will fit where a tall inline six may not. I'd say the main reason you find straight sixes in the big rigs is durability and fuel economy.