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I am the original owner of this 2015 F-150. Got a puncture on our vacation and went to drop the spare tire and the FOB key wouldn't work. We ended up ripping the lock out from the back side to get access to the hole. Today I am looking at the lock in my hand and I can see the backside of it turning but it hits a definite stop inside. It is not like it is bound up or corroded, in fact the key goes in easily and it is very clean and smooth when trying to turn until it quickly hits a stop. It acts just like I have the wrong key. Is this even possible? See pics below.
If the key turns at all, it's probably the right key.
It's a rater cheap cylinder, a screwdriver would probably be able to break it loose in the future. But hopefully you don't have to do that.
If there is a way to squirt some anti-seize inside the lock, that would do the trick. Anti-seize is a little bit of oil/solvent plus graphite (or graphene) that stays around after the solvent has evaporated. I use it on padlocks that have to live in the weather.