My bad, was thinking of passenger cars.

 

will a 5.0 aod work behind a 460 Ford

 

No. Won't bolt up, Won't hold up unless you have it built and even then it's questionable.

 

Not without an adapter and the trans would need to be built to take the torque which can be done, the AOD can be built to handle 900HP+ and over 1000 Ftlbs torque.

The more practical option is the E4OD/4R100 but they will need an external controller and a TPS on the carb. .