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Advantages - Greater horsepower and better preformance. I have been told like a 30hp gain but I never ended up doing it myself to tell you for sure.
Disadvantages - You will have to mill out the bolt holes if you plan on putting them on a 351. Also the plug angles will make it difficult because you need 90* boots to keep them from melting out on the headers/manifolds.
Overall I would do it if it was my truck. The only reason I am not doing it is because I am going diesel and dont see the point in spending the money if I am only going to change out the motor soon down the road.