I am planing on upgrading my 1965 F250 front brakes to disc. I am thinking I will use 1968 parts.
Does anyone know if the spindles are different from 1965 F250 Drum to 1968 f250 Disc?

 

I was going to post a link to Fordification but the site is temporarily down. There are always differences so the best route is to get everything from a donor truck, "I" beams with the spindles, steering linkage, brake proportioning valve, brackets for the rubber lines and the booster/master with the brake pedal.
Any disc brake F250 up to 1979 will work if you get everything from it.

 

x2 what @Crop Duster said.

1965 F250 2WD which only came with the 12 1/8" x 2" drum brakes would have different spindles than a 1968 F250. Only if you have a 1966 F250 2WD with the heavy duty 12" x 2 1/2" drum brakes (not the 12 1/8" x 2") would they be compatible.

 

If you're going to go with the swap I would go with 76-79. No matter what you go with you will still need a lot of new parts to replace all the worn ones from the donor.

 

Which front axle do you have? D44 or D44HD? There is no direct parts swap to get disk brakes on a small ball or large ball closed knuckle d44 that dont include fabrication. Youd be better off swapping in a complete axle.

 

I do believe were talking 2wd.

 

ah missed that, then theyre probably in luck! More options there.

 

Wait until dark then fill the hole with axle grease. They get that on them and can no longer fly. Sorry wrong forum.