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Do you mean sliding rear windows or is it something for the side windows?
I think you'll find the moldings either attach the window (in the case of hard plastic) or covers a gap and bolts (as the soft rubber). I had some issue with my 89's back window and I was able to chip out the chrome, leaving it all black. If your chrome is in good shape, you can just paint over it.
It looks like it's a part of the glass. Before you do much to remove it, see if you can buy it separately. If so, your going to have to remove it, it should be bolted and caulked down.
It is not easily removable. I have poked and prodded to no avail...but I did power wash a bunch of pine needles and dirt out of it...just wanted to get all the dirt out.
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