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I wouldn't want to try it - different engine if you are talking about a 2004 F150 vs. a 2004 F250 and different transmission as far as I know. (2004 f150 got the 3v Triton V8, this didn't go into the F250 until 2005). I don't think Edge makes one for your truck.
Programmers are usually specific to an engine AND a transmission if you want them to work properly. I'm sure there are other programmers that will work for your truck. I have a DiabloSport Predator in my '05 F250 with the 3V 5.4L. They make a model that fits your 2004 F250 5.4L 2v as well.
if it is a 2v 5.4 in your f150 and a 2v 5.4 in the f250 it will work fine, I had an edge evolution programmer for my 02 2v 5.4 truck and when i got rid of it i sold the programmer to a guy with an 01 f150 5.4. the evolution programmer will rear your pcm and then download the appropriate file to your pcm, the one i had would work with 4.6 liter trucks to if thats what you had.
New evolutions should have both calibrations with the option for internet updates. If it's an old style, I wouldn't take the chance, but the new ones should be good.
im looking to buy a new one and im going to buy the 2v f-150 programer. I have been looking for one for a couple months now. Does anyone know whats better or prefers the edge over the diablosport???