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There are lots of things under the truck that need to be greased. Of course any grese fitting is obvious. Some newer trucks don't have the fittings, so they are permanently sealed.
Other things needing grease include the parking brake cable, and spots where cables slide, the shift levers on the tranny, probably a few other things I missed. Look around, if it looks like it needs grease give it a shot. I like spray white lithium grease for most items that don't have a fitting. Good on door hinges, locking latches etc.
The newer the truck, the fewer the grease fittings. (I really do not like that very much. Oftentimes, "lubed for life" means a very short life, I feel.) But, if it has a greae fitting, by all means grease it--and do so at every oil change.
Ford's molybednum disulfide grease--available in tub or in tube for a grease gun--is really marvelous stuff. Of the strictly automotive greases, I truly think it has no equal. (Of course, there are some aircraft-grade greases out there that are awesome. Some of the aftermarket greases--such as Lucas X-tra Heavy Duty--are fantastic.) Still, the moly grease is available from Ford (of course) as well as Valvoline, Tractor Supply, and Wal-Mart. Quaker State offers it as well. It is really THAT good!
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.