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I have a 351c 2v auto in 68 f100 new plugs and wires,dist,carb. Its missing really bad shakes violently at idle smooth at freeway speed.slight popping out drivers side at about 35.:
Could be a multitude of things, the question is much too general, sorry can't help much without seeing truck in person, but here goes:
Look for vacuum leaks, plug gap closed, wires off, cracked cap, cracked rotor, bare/shorted ignition wires, carb/float level. Backfiring out exhaust can mean too rich a mixture, can also mean it's way out of time, or you can have a burned exhaust valve too...
Try a compression test and leakdown test also. Have someone put the engine on a 'scope and check the ignition if you can't nail it down.