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I just tried this in my 2018 F250 and it worked. My truck isn't a daily driver, so my results may take a while to see if the mpg is still optimistic!
Hopefully a daily driver will adjust their number in the engineering stetting screen AFE bias, and report back to us. https://www.f150forum.com/f118/fix-i...inutes-421912/
How much is yours off by? I was concerned about the same thing, so just over 8000 miles ago, I began tracking mileage with an app.
What I have found is the onboard computer is high as often as it is low. It is normally within 0.2 MPG. On the last tank, the truck showed 16.4, and the math came out to 17.0 over 450 miles
Keep in mind, especially if you have the really long 48 gallon tank, a few degrees of angle when filling can impact capacity by quite a bit. If you want to do a precise test, fill twice at the same pump, facing the same side, filling to the tippy top (fill the neck, assuming you have a diesel), then you'll get an accurate test. With this method, I've found that my MPG gauge is really close to correct.
BTW, I don't normally fill the neck all of the way up unless I'm doing a test. It takes quite a while for the bubbles to keep popping to allow you to see a liquid level in the neck. I also would want to drive at least 20 miles or so to burn some of the fuel before parking. If it is filled to the brim and then gets much warmer, you may overflow a little fuel. And, of course, don't do this if you have a gasoline engine with a vapor recovery canister!