I have a 2003 expedition 5.4L that has a #1 misfire I have changed plug and boot-coil and still have the misfire what am I doing wrong

 

You're throwing parts at it instead of diagnosing it.

 

Could be the plug, injector, or wiring to the coil and/or the injector.

I'd try to verify that the coil and injectoris getting the signal to fire from the pcm before throwing more parts at it hoping something sticks.

 

The coil and injector should have 12v to them when the ignition switch is in Start or Run which is easily tested.
The other wire in the coil and injector connectors go to PCM where it will be grounded/opened at the appropriate times to fire the coil or injector.
The 12v power to run the coil and injector can be traced to the PCM input connector to see if the wire is not broken.
With 12v getting to the PCM control lines properly the only part left is the grounding component inside the PCM.
The injector may be clogged or not responding so swapping the injector with #2 might help isolate the problem.

 

I changed all the coils and injectors problem solved

 

A misfire can easily be one degraded $3 spark plug boot or water inside the boot.
Once a misfiring cylinder is identified tracing the problem is fairly straight forward.
Checking the wiring is easy and low cost.
New plugs and boots aren't that expensive.
The coils rarely go bad, but can.
Injectors are even more less likely to be worn out.
Finally, the PCM may have a bad component, is not easily repaired, so is usually replaced.