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I have replaced the ignition coil, spark plugs and wires and also put in a new ecm. It cranked and ran fine for about 15 miles and then suddenly i no longer have any spark. Fuel pump primes injectors and cuts off. I am stumped.
Have you tried sitting down with it, offering it a beer, and really asking it what's wrong?
Joking aside, yardbird may have hit the nail on the head. My '85 Mercedes-Benz 190E suffered from a failed ignition control module that would get heat soaked and leave me without spark after driving down the road. Car would start just fine once it cooled down. Went so far as to toss it in the freezer after letting it heatsoak by letting the car idle in the hot Texas sun to speed the process. The chilled module started the car back up right away. Replacement module and applying fresh thermal compound under the unit where it mounted to the wheel well solved my issue.
I did forget to mention in the original post that i have also changed the distributor as well. Came with new module as i thought was the original problem before I found out the computer was fried.