I have a 2000 v10 4x4 with about 250k on motor, I have put New fuel filter , coils, plugs, and,drawing gas tank .. new,strainer on fuel pump.. I do clean and drain the fuel lines with air as well.. she starts up fine , but when I accelerate too drive she sounds like poop.. I sprayed the throttle sit ehter, and I also added 108 plus to tank as,well
Need help and ideas..

 

Check the catalytic converters.

 

Is the fuel pressure holding at speed?
With no codes, good fuel pressure and running fairly smooth the exhaust might be clogged.
Our 2003 Exped 5.4L started feeling sluggish going up long, steep hills.
It used to cruise up the hill near us at 70mph no problem.
Then it seemed to not be able to hold 65mph up the hill, then 60mph.
It would start fine, rev great not in gear, but try to accelerate or climb a hill and it would bog down.
Accelerate slowly and it would go right up to 65mph.
I found on line a vacuum test that can be run to check for a clogged exhaust.
I've seen an exhaust pressure tester lately than plugs into an oxygen sensor port for $22 that checks it directly.
At least one of my cats was clogged, probably from the misfires I was trying to figure out when I was first learning about these engines.
Changed the cats and it has run great for the last 8 years.

 

I removed my cats 18months ago and it's been great ever since (except for the obnoxious odor from the tailpipe , and extra noise in the cab, and the continuous Check Engine Light.)