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I think your question may be in the wrong forum, but I'll try and answer anyway:First, where do you live that your interstate speed limits are 75mph? and what transmission do you have behind that 4.2?? auto overdrive or manual overdrive?? and what gear ratio is in the rear end?? seems to me that your truck empty, with no load should be able in stock, factory configuration should handle 70-75mph with no problems.
A moderator will move this thread soon I'm sure, but I'll go ahead and add my comments now.
Short answer - The rev limiter will kick in long before you're doing enough RPM's to damage the engine. If 75mpg was going to hurt the engine, then there would be ALOT of engine failures due to this.
The computer has a top speed limiter and a rev limiter. 75mph with overdrive will not hurt the engine at all. It will probably not be turning but about 2000 to 2200 rpm.
Now if you had no overdrive and 4.56 gears, that's another story. It will be fine @ 75mph.
Jimmy