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Good question. I've noticed the radiator in my one truck with the 300 is WAY smaller AND thinner than the radiators in either of my 352 trucks. And, despite that, the 300 still seems to run cooler than either of the V8 engines. Two more pistons and some extra cubes at least. Might also be more friction in a V-8 with the lateral movement of the pistons in the bore.
Others will chime in, I'm sure.
Oh, the 300 also has the Extra Cool Radiator, whatever that gave a person. You can see it on the invoice in my album here. But, so did both of the V-8 trucks so that's a wash.
As I recall, the I-6 radiator has the upper neck on the opposite side vs. the V8 radiator.
The radiators used in 1965 F100/250 2WD's are different than the radiators used 1966/79, as the '65 F100/250 2WD radiator support is different, so the radiator mounting flanges are in a different location.
btw: L6 is the designation for a Flathead 6, not installed in Passenger Cars/Trucks after 1951, as the OHV I-6 (215 cid initially) was introduced in 1952.
The 65 with the T-18: swapped a 302 for the 300 in late 70's and kept the same radiator and never experienced an overheating problem. Fortunately able to refer to a later model truck in finding inlet/outlet size hoses for the correct location. If already have, or intend, adding auto trans then may want to consider going with radiator that includes the trans cooler. Having said than, finding a replacement can be problematic? If don't intend adding auto trans, knowing what I know now, I would see if the existing radiator would supply sufficient flow to maintain proper heat for the 352?