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You definiatly need new tunes if you didn't have the computer adjusted for the larger injectors. I am running the Looney WIld tune from vivian at Quick Tricks and couldn't be happier. Stupid fast.
As far as a turbo goes I would go for a powermax if you want to remain the versatility of the 6.0.
Just my .02.....
But definiatly get a new tune on there with those new injectors. and don't tow with a hp tune only a tow tune. found that out the hard way.