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I don't know what you call problems? Will the tires throw water and mud so the engine and everything under the hood get soaked and covered in gunk in bad weather? I'd say yes. Not much different than driving without hood and fenders. Depends on how much cleaning of baked on dirt you want to do. Seems diametrically opposed: Use a flip front end to show off the engine and it's surroundings and not keep them as clean as possible.
With all the work and money I am putting into this truck I hope I don't get stuck in bad weather, but I really never thought about the lack of inner fenders. I only thought about how cool it would look when opened, and how much potential rust I wouldn't have to deal with . I had a whole set of steel when I first started collecting parts and I ended up selling and trading them off. I am fortunate that the cab and doors are rust free.
I bought a 78 Chevy step side when I was 16 and started tearing it apart. Over the next four years I had everything off the truck and replaced except the cab. I learned a lot from that truck, but this one is learning at a college level. When I first started collecting f100 parts about five years ago I thought it would be about bolting parts together to get a truck, I have learned more in the last week then I learned during the previous truck.
I'm sure you can fab up some inner fenders. It would be cool to adapt some plastic fender liners from a modern truck that raise/lower with the tilt front end.
Rezvani's Latest Post-Apocalytic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.