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my brother has a 2000 harley davidson f-150 with a vortech s-trim blower on it and later installed the diablo chip. the horsepower from the chip was more than enough to feel. it might not be as noticable in a nearly stock expedition but in my opinion the diablo is the way to go.
They both claim the same performance gains and I'm sure they both do it the same way, by advancing the timing a bit. I've studied posts on this board and F150 Online for the past few months and believe the Superchip is much more popular and haven't heard any negative feedback about it. Thus I'm going with the Superchip if I ever decide it is worth the added costs of using super unleaded.