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I've got a 78 F250 with the 400 in it. For the past 4 years (after I got a new engine), I've had an Edelbrock 750cfm on it. I decided to change to a 600cfm to get some better mileage and improve daily driveability, so I put the Edelbrock version on.
When the truck is cold, and I'm trying to accelerate at light throttle, it burps out into the headers and loses power, but it doesn't backfire out of the exhaust pipes. If I give it more gas and try to accelerate at medium (or higher) throttle, it seems to bypass the problem and doesn't do it.
I have an air/fuel meter (the cheap variety with the lighted bars), and it's showing a slight rich condition, which is what it shows at cruise. So, that seems fine.
It kind of sounds like you distributer isnt advanceing. If you have vacuum advance, make sure it is functioning properly, if you have weights to, check them....
Keep in mind, a rich mixture, when hitting cold air, may rumble a bit, or pop even.
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