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I know a guy who ran 35's on the next gen of f150 and didn't trim anything, they didn't rub unless he flexed the suspension but that happened pretty well over every bump. I don't know if your gen and his have the same clearances around the fenders though.
whats the biggest sized tires i can run on a 1980 f150 with no lift ive heard 32's with minor trimming but im not sure
i had an 81 f250 which i beleive are very similar and i was able to run 36 with little trimming but if your looking to flex i wouldnt go any bigger than 32 imo