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I once took a radiator from a Dodge Reliant K car and put it in an early Bronco with a 302. I was desperate and just needed a quick fix. It worked so good (aluminum) it stayed in the truck for a couple of years and was still in it when I sold it. So, if you're on a budget, I'd recommend giving the rad you have a try. I think the two row would be fine.
An issue that will come into play, is the radiators have either an inner flange, or outer and want to make sure the radiator flange matches the support. Originally had a 6 cyl. in 65 F100, it was a small radiator and assume it was a 2 row. Swapped the 6cyl. for a 302 and kept the same radiator for 20 plus years and never had an overheating problem. Rebuilt the 302 few years ago and thought it would be a good opportunity to install a larger radiator in the event I decided to install an auto tranny at a later date. What a mistake, this is when I learned about the inner and outer flange. Further, not sure if unique for my particular truck, but the radiator sets inside the support which made finding a replacement more of a pain in the backside. Wish I had left well enough alone, if had to do over I would likely had it record, although, never checked on the cost. Now don't intend to install an automatic so for my purposes prefer the T18. Anyhow, had an urge to chime in and add my $.02.
The difference...in a nutshell is the side straps... IF the hose inlets/outlets are different between 240/300 that would be the only other difference...IF they are different which I do not know as I havent laid eyes on a 6 cyl. radiator in a cpl years...
BTW, the side straps is the difference in the FE truck radiators used on F100/250 2wd between 65 and 6...and I know those tanks are the same between the 2....
I'd buy the cheaper two core and if the side brackets are different (50-50 chance), use the brackets from the original rad. Any rad shop should be able to move those for you! IMHO!
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