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In what?
If you haven't changed it in the trans you have in the listed 250, then now is a great time.
Some ppl do every 30k, or 60k, just depends on the school you went to.
Here is a link to the tech article for the process of doing the change. https://www.ford-trucks.com/article/...nsmission.html
The link Steve_250 posted needs an update. MERCON V is now the right fluid, MERCON has been discontinued. Other than that it is an EXCELLENT procedure.
Clamp the clear hose to the line you took off of the trans. If everything is working correctly that's where the fluid will come from. If fluid comes out of the fitting on the trans there is a restriction in the coolers or cooler lines.