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The truck needs larger injectors and a tune for it. Methanol's a/f ratio is even richer than ethanol and it needs about 50% more fuel. It'll run like a scalded dog properly set up but the mileage will suck.
If its not tuned for it will runway too lean.... boom!
If you are not familiar with methanol, you should do some research.
Your health, safety, and even life depend on handling this poison properly.
If you value your vehicle, likewise. Fuel components made of steel, many gaskets, some rubber and plastic-like items will suffer and fail with methanol.
This is a pro-methanol site obviously, and there is enough in their "Use of Methanol as a Transportation Fuel" report of 11/07 to waive off most folks.
(from the main page, click on "Alternative Fuel", then look for the above title)
Research E85 and its octane and availability instead....
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.