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I just found a 48 F500 on craigslist real reasonable, and had a couple questions. Are the fenders bigger on the F500 than on the 1/2 ton trucks? And what about the frames on them? This one is a dually so is the frame bigger in height than a half ton? Could you put a mustang II front end on it? Was thinking of making it a hot rod truck but wasn't for sure on the chassis situation.
Now then, on to your questions. Yes, the fenders on an F-500 have larger openings than the F-100. I believe the frames are also heavier, but I don't know for sure. Someone who can be certain will be along shortly, I'm sure.
Personally, I'd suggest maybe keeping it a big truck. There are tons of F-100s floating around, the bigger trucks seem far less common.