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Since you're asking about performance chips, I'm going to assume you've got a diesel, and since your profile says your truck is a 2006, I'll assume it's a 6.0L. (moved to 6.0L section.)
Keep in mind that with performance chips/programmers/etc., while they can help mileage slightly, it becomes exceedingly difficult to keep from mashing the pedal all the time. In other words, you'll want to use the power because it's fun!, and thus mileage may suffer a tad.
contact a custom sct dealer and they will hook you up. Sct is the only chip that is truly safe on trannies and is completely customizable to your truck.
This Hennessey Takes the Expedition Tremor's Off-Roading Capability to the Next Level
Slideshow: The VelociRaptor Expedition gains a lift, upgraded suspension, Brembo brakes, and trail-ready equipment while retaining the stock 440-horsepower EcoBoost V6.