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the sweet spot you are talking of is related to the torque curve. torque is the ability to do work under load. theoretically, if you ran a mildly higher rpm with a larger improvement in torque - you may be able to put less fuel through to maintain that rpm. you may be right, i just have never seen it in average wt vehicles. a ford engineer out of the engine dept could answer this question.
If you are not towing anything the vehicle is not constantly under load and will "coast" if you will from time to time and mileage will vary with the amount of coast time...
I tow for a living and I guess I was think about while under a load or on a grade where you are constantly calling for fuel...then yes more rpms mean more fuel!
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