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First of all, I'm not new to wrenching but new to Fords and only really have experience with steering and suspension, brakes, etc. I.E. be as technical as you wish.
I have a 2000 F-150 with a 5.4L V8, and just under 100,000 miles. The CEL came on about a week ago and I pulled P1127, P1780, and P1703 out of it. It's running fine but has extremely poor fuel economy. It was suggested I replace the bank 2 O2 sensor but I wanted a few other opinions before I dig into it. Plus, is there not 2 bank 2 sensors?
Code 1127 is down stream Ox sensors not hot enough to test.
Code 1780 is Transmission control switch out of test range (OD).
Code 1703 brake switch out of test range.
You have such a variety of codes that it seems it may be fuses are out or there are wiring problems.
The cold ox sensors condition will greatly affect fuel mileage if the engine is running in open loop, as a result.