I run an SBC in my 56, but it goes in without any problems that a frame swap solves. I'm not trying to disuade you because of any brand loyalty or anything like that, I'm far from one of those. I will try to offer reasons why NOT to follow other's mistakes. It's just that there are easier and better means to an end than doing a frame swap, and especially to a frame that doesn't fit. I really would like to see pictures of your friend's successfully COMPLETED S10 frame swaps, I have seen a lot of pictures like the site linked above where a frame swap was started, but never finished when the builder finally realized they were in WAY over their head, but none of one completed. Mounting the cab is NOT the hard part, getting everything else to fit and work right takes a very skilled fabricator. They typically end up looking like a Monster truck, or a full size body set on a toy chassis.
F1 frames are much cheaper than S10s, to install a CSB only requires a bolt in crossmember for the engine and tranny same thing an S10 frame needs. A Jag IFS is a bolt in swap that gives you a suspension designed for excellent ride and superior handling as well as R&P, Disks, swaybar and are as cheap/cheaper than an S10 roller frame. A Ford 9" is also a bolt in swap.
I am not totally against frame swaps, just against doing a lot of work that makes no sense, the S10 just plain doesn't fit which in my book doesn't make sense. If there was a GOOD frame swap out there I'd say go for it.
If you have plans to make a fenderless Ratrod, just say so, we (at least most of us, as long as they are built safe and hopefully with some esthetics) are not prejudiced against them either, and I won't question the frame swap then, because fit doesn't matter. Note the sketch I did of a ratrod concept in my extras gallery.

 

Nice article but the shortcomings of the S-10 frame for an Effie are obvious. The loss of seven inches of depth in the bed would be enough of a turn off for me. I agree with the others after seeing the article. You would be better off modifying a stock frame. Believe me when I say I'm one of the most frugal persons on FTE and I would not use the S-10 even if I had a free one. It is just too small and narrow. I'd seriously consider another plan...

 

Thanks for your insight guys. I'm just starting out so things will probably change as time goes on. As far as my buddies '53 goes I'll try and get some pics the next time I'm out at the shop. He is actually using a '46 bed and moved the cab back on a S10 longbed frame and massaged the front fenders so it looks better. Probably the bed on my truck won't be really functional either but that isn't a real concern as I have another truck.