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Hesitation or flat spot can be either carb or timing. Make sure your distributor mechanical and vacuum advance is working properly. Make sure the carb accelerator pump is working.
There are threads here on how to test both of these systems. The carb forum has more carb info.
Unfortunately backfiring can destroy the power valve on the stock carb. The carb forum will have info on testing and replacement.
Have you messed with your plug wires lately? I did a tune-up on a 460 once and it started backfiring when I gave it gas, it turned out I had swapped 2 plug wires.
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.