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Found this tire size calculator. For a stock tire using my tire as stock and yours as new. Stock turns 637 times per mile and the new is 587 times per mile. Speedometer reading will be 8.6% slow or with new tire your speedometer will read 60 but the law if he is around will say your doing 65.1 MPH
So with these calculations I would be pretty sure it will take a lot more HP to go down the road especially when towing. Then the fuel mileage would go down.
On both of my powerstrokes i've owned I have never been higher than about 11.5 mpg towing my toy hauler. Empty the best has been about eighteen with downhill grade and lower elevation. It would be interesting to know what elevation the 18+ mpg guys are running. I have had 35's on both trucks.
Thanks bigredtruckmi! Any math wizards out there that could do the exact calculation? Good point Fasttrax. I hadn't thought about elevation. I live at 4400 ft above sea level and when I tow, it is up to between 6500 and 10000 feet above sea level. Any higher eleveation folks getting the 18-22 mpg?
I live at 8,000 ft and frequently drive to Colorado, anywhere from 6,000 to 11,000. My last two trips have seen 21 mpg highway from NM to Colorado Springs and back via LaVeta pass.