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yes you can put a exhaust system on a 2000 f-150 no problems. i have put the following "performence" parts on my truck and have seen results in all- "superchip", K&N cold air intake w/filter and Flowmaster exhaust 40 series w/3in tips. I see a, what i would call, dramatic decrease in gas milage when the chip is in (15 to 12) but if you want 20hp that you can feel go with the chip too. all n all when i installed each of the parts i noticed a difference, either or both, in performence and sound. to give you a perspective on how much difference it made for me, my 0-60 (5.4L) before i did the upgrades was 9seconds now it's right at high 7's low 8's!- so to loose a whole second is always a plus.