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Well there are multiple ways, I dont know that one is best though. You might try:
1. low restriction air filter
2. Headers
3. Ported lower intake and heads
4. Comp 410 cam
5. High flow, or no, cat converter.
6. Dual exhaust
7. Supercharger
8. Nitrous
9. 95-97 closed chamber heads, which up the compression ratio, not for use with #7
That's about all I can think of now. My brain hurts.
If you dual out the exhaust pipes on the truck, be sure to put an "H-pipe" BEFORE you get to the cats. Believe it or not, the H-pipe will boost your torque over two straight--and unconnected--exhaust pipes!