6.0 in an Econoline
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It depends on what you mean by harm. In a sense you harm an engine, any engine, everytime you start it. Operating the engine cold, like just after starting it, does accelerate the wear and tear on the engine. Thermal cycling, heating and cooling cycles, will also tend to accelerate wear and shorten engine life. Multiple short trips, where you shut down for a short period and restart before the engine cools is probably less harmful than a complete cool down and restart. If what you're asking here is "Will I significantly reduce my engine life?" I would say that is highly unlikely. Reduce, yes. Reduce a considerable amount, no. Manufacturing tolerences and random chance are probably more likely to shorten engine life than your driving habits.
Regards,
Morris
Regards,
Morris