I got a 92 ford f150 4x4 e4od with a 88 ford Econ line 5.0 motor and it has a manual 4x4 shifter and the 92 e4od trans I’m trying to put in it has a button on the dash for the 4x4 can I use the transmission or not

 

You lost me. You have a ‘92 F-150 4x4 with an E4OD and manual transfer case. You want to know if the ‘92 E4OD transmission you want to put in it will work?

 

I think he's saying the original trans has manual t-case, but the new one is electronic shift, or vice versa?

Or wait, which one has the button on the dash? The truck? Is the engine/tranny with the manual shifter in the truck already? now I'm lost

 

The transfer case is irrelevant since the one that is currently in the truck will be reinstalled.

 

Ok. If the t-case is irrelevant, we've confirmed his question. "Will an E4OD originally mated to an manual shift t-case also mate to a t-case with electronic shift?"

Of course we're assuming his t-case is not broken along with the tranny it's mated to.

 

That was my confusion. The OP asked if he could replace a ‘92 E4OD with a ‘92 E4OD.