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For a 65 f250 with four speed with granny low. I would like to keep that transmission in it but wondering about putting a 5.0 in it... Currently has a 300 inline 6
If you are talking about a Windsor 302/5.0 it should bolt up to your bellhousing. Not sure if the engine perches will need to be swapped out but this should tell you. Comparison Photos of Engine Perches - FORDification.com
I would think that the perches out of a 70 -72 with factory 302 would work.
I sold a small block bell housing, fly wheel, and the perches to a local guy that was swapping out a 352, and installing a later 302 in a 66 f100.
We looked at my cross member, and things looked pretty close.
I never heard if he had to drill more holes, for them, but I know he used them, and the truck used to be driving around town.