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every now and then my throttle will not work even all the way down. And sometimes it jumps while at a slow speed... 2001 f250 7.3... can this lead to power loss nd low mpg?
I don't think this would affect your fuel economy, it sounds like you have an electrical issue between your throttle pedal and PCM. Just a wild guess though.
Same happened to me. I was able to remove my TPS and clean it up with contact cleaner. Been good ever since then. Make sure the contact cleaner is safe for plastic.