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One VERY important thing to add to your truck: the plastic inner front fender liners like were used in the 77-79 trucks. Get the splash shields for the rear wheel wells too. Paint the front fender area inside as others mention, then pop the access plate off the cab mount. Spray motor oil inside there, & on the backs of the fenders. Then install the fender liners.
Another great product to look into is Fluid Film. It really is a great product. However it too is a once a year application, but only in areas that routinely see water. Such as the chassis of the truck. If you want to see pictures of how it performed after just one year of use check out this thread in the 09-14 forum. https://www.ford-trucks.com/forums/1...s-applied.html I should add that you can get tis product in both 1 gallon pails and in spray cans. I've priced the gallon pails with applicator gun for about $80 US. This product has even been known to stop existing rust dead in it's tracks.
I thought about doing this to my 75 but, never did. From the inside of the bed, over the wheel well drill a hole to get access to the area over the wheel arch (where they usually rust). Use air to blow out any Arizona sand or what ever has accumulated and apply whatever you might use, a rubber plug such as used by undercoaters can be used to fill the hole.
There is no need to drill a hole to access that area. You can get to it from underneath the truck. Either just in front of the rear wheel, or just behind the rear wheel. And if you have a long bed truck you can access it from the top through the center stake pocket.
The bottom of the stake pocket is open. If you down into it you'll the top side of the outer wheel house. The piece often times referred to as the inner wheel house.
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.