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I would probably go with wider tires, but a lot depends on compound, tread pattern, inflation, gearing etc. the main thing I would make sure of is that the tires are rated to handle the GAWR(Gross Axle Weight Rating) for each axle. If you go under rating, you might risk a blow out with a full load.
The skinnier tires will work better in snow and give slightly better mileage(yeah right). Once again all the issues mentioned above wil change the reality of that particular tire. I have used skinny tires that were great and some that were dangerous. Ditto for fat tires. One gottcha with fat tires is they often do poorly in snow or rain.
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