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Some 4.6L engines will have two knock sensors instead of one like the Explorer uses. Other SOHC engines should work, it just may be hard to get around the wiring issue.
I have read about people putting Mustang 4.6L engines in the Explorer. The cast iron block vs. aluminum does not seem to be an issue.
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.