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Mines got 260k on it and still doing great. I know of another one just like mine with 300k and driven every day. How long should they go? Who knows. Take care of it and see. Just curious, does anyone happen to know what the highest ever recorded miles is on one of these trucks?
Highest mileage Modular I know of is in an E-Series van, a '97 5.4L, with over 1.2 million miles without a rebuild.
Most Modulars are taken out, barring poor maintenance, by either a bad fuel injector, a bad wrist pin bushing or a timing chain/guide failure. If the wrist pin bushings are in spec from the get go (by far most are), and the fuel system well maintained, they go well over 300K on average. Timing chain guides begin to get "iffy" above 300K.
If you've got a good running, high mileage Modular, replace the timing chains/guides/tensioners around 250-350K, you'll likely have an engine that goes beyond 500K. They just don't seem to wear out within a reasonable time, even the really high mileage Mods show little cylinder wall or bearing wear if decently maintained.