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The other problem you will find is that no one makes a chip for the E Series PSD. Just the F Series.
I've got a 2000 E450 box truck with the 7.3 PSD and 4.10 rearend. I bought it at 102k miles. When it needed rear tires at 135K, I bought 19.5" rims and 225/70R19.5 commercial tires. The speedo and odometer are off about 12% low now, but the truck still has plenty of power, gets better mileage, runs at a lower rpm on the highway and seems much more stable with the bigger tires on the rear.
I can say again, the turbo is not the same, it has less boost as the F series, if you change manifolds and such with the F series basically turning it into one, you can look into chipping it. I read about a guy who bought a 99 ambulance, retrofitted it into his 76 E-250, then used the truck turbo and setup, he has it chipped. He's on vannin.com
If I had a lighter truck and was not towing almost every day, I might try the taller tires, but in my case I don't think it would work. Also my rear is 373.
How much boost should I have? I am installing the gauges on this week.
Another way to get more air in for cooling, beyond louvering or adding a scoop on the hood is to fabricate some under bumper scoops with tubes bent to cool the front, and sides of the engine as well as a pair to cool the brakes. I am trying this on my 74 E-300 as heat is a real problem with this body style. I will drive this van till I die and will play with it till the very end. Old Vanners never die, we just need very large coffins to take our toys to heaven with us!
Louver the fenders to get the air out, air flow through the front is restricted to the speed it can exit. I had a friend in the rescue squad, the 460 in the 80's ambulance was prone to overheating, vents set on the hood for letting the air out solved the problem.
A turbo diesel generates a lot of heat, and due to room restrictions, don't have a cooler on the intake, limiting power production, good luck trying to find a place to put one. Lets not forget the dog house temps, the 5.4 in my 99 is at operating temp according to the gauge, but my radio is so hot, the CD's you can't handle, and no I can't insulate without tearing out the entire dash, engine compartment is too cramped to add there.
The stock electric fan from a Lincoln Mark VIII is one of the most effective cooling fans ever made. It puts the over-advertised aftermarket fans to shame for cooling CFMs. If you need more cooling go to eBay and pick one up for $100. You will need to make sure you have a good alternator though, to move that much air they take some serious amps.
They seem to be all the same. There are 16", 17", 18" fans for the Lincoln. The Lincoln Mark VIII is the nice big 18" one. It has mostly straight blades which are unusually wide at the outside of the blade. The 17" blades are skinnier overall, thickest at the middle, and are swept back in kind of a banana shape.