When you click on links to various merchants on this site and make a purchase, this can result in this site earning a commission. Affiliate programs and affiliations include, but are not limited to, the eBay Partner Network.
Based on what I've been told in the past by others on this site, leaving them locked in won't cause any problem with high speeds. You may notice some axle bind on tight turns with dry pavement (and I assume you will not be making any tight turns as HIGH speeds - at least not on purpose).
Even with the hubs locked, you still are not in 4-wheel drive until you engage the transfer case (via a shift lever in the cab, or the dash switch with ESOF). The front axle will turn though, and some say this causes additional wear and greater fuel usage. Once you engage the transfer case, you can still drive at high speed, but you will use more fuel (engine now has to turn the front axle also) and you will notice much greater axle bind on tight turns with dry pavement (and I think you can break things in this instance).
This Hennessey Takes the Expedition Tremor's Off-Roading Capability to the Next Level
Slideshow: The VelociRaptor Expedition gains a lift, upgraded suspension, Brembo brakes, and trail-ready equipment while retaining the stock 440-horsepower EcoBoost V6.
Rezvani's Latest Post-Apocalyptic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.