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You cannot simply shutdown a cylinder without changing the software in the computer too. Each and every time the computer thinks a cylinder should have fired, it checks the crank position sensor and looks for crank acceleration. If that acceleration isn't seen, the fault will be recorded as a misfire and after a few of these your check engine light will come on. When that happens, the computer will start trying to accomodate a problem which it interprets to be an ignition misfire problem.
You also cannot monkey with the timing because the computer will readjust it to where it thinks the timing should be.
If you do start messing with this, be darned sure that you keep fuel from getting to that cylinder. That fuel will get routed right out the exhaust valve and down the pipes to the catalytic converter. Unburnt fuel running through a cat will destroy the converter.