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4.56 would be my choice, if you ever go bigger on the tires you would still have enough gear. I have 4.10's in my truck with 33's, I wish I had the 4.56's. If you do any towing you will love the power you will have. Good luck
I have an 01 250 5.4L CC LB W/35" tires and I have the 4.56 gears front & rear. Installed here in MS. for $1400.00. I am very happy with this combo of gears & tires. It doesn't shift out on hills and over passes any more. It pulls HARD too.
I would say if your keeping 33s on your truck you'll be fine with 4.30s. So you will wish for lower gears 4 days a year and be happy 361 other days. I could live with it!
After talking with a bunch of people that own F250's and the driveline shop I have decided to go with the 4.56 gears.
With 33" tires my actual gear ratio will be right at 4.30 so that will work out really well. I also looked at the RPM difference between the 4.30 and the 4.56 gears at 65-80mph and the difference isn't that much. When my current tires wear out I will probably get some 35" tires and a 3-4 inch lift.