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from what i've read the 460 actually came in some car or the other in the 70's. not sure which one, but i'm sure i read it somewhere.
Ideally you should use something that looks like a beater. maybe a 80's LTD, preferably a old police cruiser. The only issure with using a bigblock in a car is that you may not have enough clearance above the engine, which would require a cowl hood. if you can get away with the clearance, it would make a for a hell of a sleeper.
Rezvani's Latest Post-Apocalytic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.